An elevated sperm DNA fragmentation index can lead to decreased natural pregnancy rates, increased probability of miscarriage, and decreased IVF success rates. To reduce the sperm DNA fragmentation index, we must first treat the cause, such as treating reproductive tract infections caused by mycoplasma and chlamydia, surgically treating varicocele, and taking oral antioxidants, such as vitamin C, vitamin E, and coenzyme Q10, etc. Chinese medicine is also widely used in clinical practice. In daily life, we should avoid smoking, drinking alcohol, being sedentary and staying up late, avoiding exposure to high temperature, chemical and radioactive substances, and actively participating in physical exercise.