High thyroglobulin antibodies in pregnant women need to be combined with peroxisomal antibodies and thyroid ultrasound findings for a comprehensive analysis. Elevated antibodies with echogenicity generally indicate the presence of Hashimoto’s thyroiditis. In early to mid pregnancy, TSH should be controlled below 2.5 and in late pregnancy, TSH should be controlled below 3. If TSH is elevated, additional treatment with levothyroxine tablets is recommended. High thyroglobulin antibodies in pregnant women may be due to the fact that pregnant women are prone to endocrine disorders during pregnancy, resulting in abnormal thyroid secretion in the body, which leads to high thyroglobulin antibodies in pregnant women.