The use of potassium permanganate together with povidone iodine may lead to the development of dermatitis, skin irritation and other adverse reactions. Potassium permanganate is used to destroy bacteria and pathogenic microorganisms through strong oxidizing properties, and is usually commonly used in sitz baths or immersion. Povidone-iodine is also a commonly used disinfectant with less irritation to skin and mucous membranes, and is mainly used for rubbing disinfection, daily wound disinfection and puncture disinfection. Both have a certain degree of oxidizing properties, and simultaneous use may aggravate adverse reactions, such as dermatitis, allergies and other discomforts, manifested as local skin redness, swelling, itching, blisters, vesicles, etc., and prompt medical attention is required in the event of the above situation. If you have to use them together to improve the disinfection effect, you should soak the disinfected area with potassium permanganate first, and then rinse and dry it with water before rubbing povidone-iodine on the disinfected area to reduce the irritation caused by mixing the two.