Unstable pain can be seen in autonomic dysfunction, calcium deficiency, rheumatoid arthritis, etc. Patients should consult a doctor in time to clarify the cause of the disease and then carry out treatment. 1. Autonomic dysfunction: a group of syndromes caused by long-term mental tension and excessive psychological pressure, patients will have immobilized pain, chest tightness, breathlessness, insomnia and forgetfulness, menstrual disorders, etc. Such people should relax, take appropriate exercise, and if necessary, can be treated with ghrelin and propranolol. 2. Calcium deficiency: caused by insufficient intake, excessive excretion or utilization disorder of calcium in human body, patients will have wandering and immobile pain, twitching, weakness and easy fatigue, such people should actively search for and treat the primary causes of calcium deficiency. At the same time, vitamin D and calcium supplements. 3. Rheumatoid arthritis: autoimmune factors such as erosive arthritis, patients will have fever, fatigue, generalized immobility pain as well as swelling and deformation of the joints, and can be treated with ibuprofen, salicylsulphadiazine and so on. Generalized high fever can also cause symptoms of unspecified pain in the body, and requires causative treatment for the cause of the fever. All of the above medications and treatments should be administered under a doctor’s supervision.