Aminotransferases include both glutamic and glutamic oxalacetic aminotransferases. Either aminotransferases over 5000 IU/L indicates a very serious condition. The upper limit of normal aminotransferase is usually around 40 IU/L. Usually, if it is more than 10 times the upper limit of normal, it indicates severe liver damage, while aminotransferase over 5000 IU/L indicates very serious liver damage. Common causes of liver damage may include drugs, alcohol, viral hepatitis, autoimmunity, metabolism and ischemia and hypoxia, all of which can cause increased aminotransferases. If it has exceeded 5000 IU/L, it indicates serious damage to liver cells, including hepatocyte membrane damage, mitochondrial damage, and serious liver cell damage can even lead to liver failure, which may eventually become life-threatening. Therefore, if transaminases exceed 5000 IU/L, it indicates a very serious condition. You should immediately go to the hospital for biochemical tests, virus tests, immune tests, abdominal imaging tests and other examination methods by doctors to further clarify the cause of the disease, and at the same time give active liver protection and liver care treatment.