The difference between fever, cold hands and feet and heat are different symptomatic manifestations and different disease mechanisms. 1. Fever hands and feet hot: usually patients with fever accompanied by fever hands and feet, Chinese medicine believes that the symptoms of this disease and its nature is consistent. At this time, the patient’s body is overheated and the struggle between good and evil is intense, which can be seen in the whole body fever. 2. Fever with cold hands and feet: patients with fever accompanied by cold hands and feet, Chinese medicine believes that the symptoms of this disease deviates from its essence. At this time, the pathogenesis of the disease is that the internal heat is extremely high, and the yang qi is enclosed in the body, resulting in the yang qi can not reach the extremities of the muscle surface, so the patient has the symptom of cold hands and feet. If the patient has fever and cold and hot hands and feet, he should consult a doctor in a timely manner and receive regular treatment under the doctor’s guidance.