Splenomegaly has an effect on the white blood cell count if it is caused by an infectious disease, while non-infectious diseases do not necessarily have an effect on the white blood cells, and some hematologic diseases also have an effect on the white blood cells.
There are many causes of splenomegaly, and the changes in blood white blood cell counts vary depending on the cause. The most common form of splenomegaly is advanced cirrhosis, when leukopenia can occur.
Infectious diseases such as bacterial infection, viral infection, chronic viral hepatitis, syphilis and other infectious diseases lead to splenomegaly, usually with changes in leukocytes. In non-infectious diseases such as simple stasis splenomegaly, leukocytes are not necessarily affected. Some hematologic disorders that cause splenomegaly may also affect the white blood cells.
If splenomegaly is detected, it is recommended to seek prompt medical attention for further examination and treatment.