Gastrointestinal cancers (such as esophageal, gastric, colon and rectal cancers) are the most common malignant tumors in China. Some data show that the incidence and mortality rates of GI cancers in Wuhan region (including the surrounding areas) have been higher than the national average for many years. People in this region prefer salty and spicy foods as well as traditional pickled and marinated foods, which has laid a hidden danger for the occurrence of digestive tract cancers. In addition, with the accelerated pace of work and life, office workers with long-term work pressure and irregular life, as well as middle-aged people over 40 years old, are the high-risk group of digestive tract cancer. Moreover, quite a number of them are afraid of examination and hold the wrong mentality of “it is better not to be examined, but to be sick once examined”, and refuse to be examined even if they have early abnormal digestive tract symptoms. Many tragedies could have been avoided. Generally, when encountering gastrointestinal symptoms, doctors recommend gastroscopy to confirm the diagnosis. Because gastroscopy is a common means to diagnose peptic ulcer disease, chronic inflammation, polyps and tumors, and it is also the most direct and effective means. However, many patients are afraid of doing gastroscopy, worrying that endoscopy brings discomfort such as nausea and vomiting, sore throat and abdominal distension, hoping to use ultrasound, CT and other means of examination instead, which is incomplete. Take gastroscopy as an example: most esophageal, gastric and duodenal diseases, therefore, for most patients with gastric diseases, the best choice is to do gastroscopy to diagnose the disease can be made through direct observation of the lesion by gastroscopy and make an accurate diagnosis; while B ultrasound and CT are better than endoscopy for the diagnosis of substantive organ lesions, but the lesions of the gastrointestinal and other cavity organs can only play an auxiliary diagnostic role. Gastroscopy can not only diagnose gastrointestinal diseases clearly and accurately, but also determine the location, size and shape of polyps and tumors, and take biopsy directly to determine the benignity and malignancy of tumors, which is the gold standard for diagnosing gastrointestinal tumors and cannot be replaced by any other examination methods. In response to the pain, nausea and abdominal distension of gastroscopy, painless gastroscopy has been carried out in various hospitals, which can make patients receive the examination easily and free from nausea, vomiting and abdominal distension. We suggest that even if there are no obvious GI warning symptoms such as swallowing discomfort, fullness, wasting, loss of appetite, blood in stool, change in stool properties, etc., gastroscopy should be used as a health checkup for certain people, especially for those who have GI cancer in their families. So, under what circumstances should gastroscopy be done? Generally speaking, in asymptomatic cases, it is advocated to start the first gastroscopy at the age of 40-45, and to review it once every 3 years if there are no obvious lesions, and once every 6 months or a year if there are lesions such as hyperplasia and erosion. Colonoscopy is done for the first time from the age of 50, and is reviewed once in 10 years if there is no obvious lesion, otherwise it needs to be reviewed once in 2-3 years.