There is no fastest or best pain relief method for lumbar spondylolisthesis. Depending on the condition, it is often treated by resting, wearing a brace, medication and surgery to relieve pain. 1. Rest: pay attention to rest, change bad habits, avoid sitting or standing for a long time, and avoid doing heavy physical work. 2. Wear a brace: You can wear a brace such as elastic girdle to limit the lumbar activities to maintain the physiological posture of the lumbar spine, so as to alleviate the pain symptoms caused by lumbar vertebral hyperplasia. 3. Medication: Topical or oral analgesic drugs can be used to relieve pain, commonly used drugs such as diclofenac diethylamide cream, celecoxib, ibuprofen, diclofenac sodium and so on. If the pain is obvious or the pain is acute, when the effect of non-steroidal drugs is not obvious, you can consider weak opioids for pain relief, such as codeine, tramadol. 4. Surgery: If the effect of conservative treatment is not good, and perineal numbness, urinary and fecal problems occur, surgical treatment can be taken, such as total decompression of the laminae, lumbar interbody fusion via intervertebral foramen approach, percutaneous endoscopic lumbar discectomy, etc., to remove the diseased lumbar spinal tissues, so as to stop the pain. Due to individual differences, there is no absolute best, fastest or most effective treatment for pain relief, and the treatment should be decided by the condition. The above drugs should be used under the guidance of a doctor or pharmacist.