Appendiceal lymphoid follicle formation is mainly a bacterial infection of the appendix, resulting in lymphoid follicular hyperplasia, suggesting a predisposition to appendicitis. As the appendix opens into the cecum and is close to the small intestine, bacteria and microorganisms from the intestinal lumen can easily enter the appendix, thus predisposing to inflammation. The formation of lymphoid follicles is mainly due to the body’s normal immune response to inflammation, is a normal physiological phenomenon, do not need to worry too much, if the inflammation of appendicitis gradually fade, the lymphoid follicles will also gradually dissipate. Appendicitis is divided into acute appendicitis and chronic appendicitis. Acute appendicitis requires prompt surgical resection and anti-infection treatment; chronic appendicitis can be treated without surgery for the time being, and it is recommended to use antibiotic medication for treatment and close observation, so as not to be negligent and careless, so as to avoid delaying the condition. When the right lower abdominal pain, ultrasound examination suggests the formation of appendiceal lymphoid follicles, can be diagnosed as appendiceal inflammation, should be actively treated accordingly.