Increased thyrotropin receptor antibodies may be caused by toxic diffuse goiter, hypothyroidism, Hashimoto’s thyroiditis, etc. A clear diagnosis should be made and appropriate treatment should be chosen. 1. Toxic diffuse goiter: elevated thyrotropin receptor antibodies may be caused by toxic diffuse goiter. After diagnosis, patients can take antithyroid drugs as prescribed by the doctor, such as methimazole and propylthiouracil, which can inhibit the synthesis of thyroid hormones. Patients can also take radioactive iodine treatment, and can also choose surgery such as total thyroidectomy or subtotal thyroidectomy. 2. Hypothyroidism: If hypothyroidism leads to an increase in thyroid hormone receptor antibodies, the patient should take levothyroxine as prescribed by the doctor, and if necessary, the drug should be used for life. 3. Hashimoto’s thyroiditis: Hashimoto’s thyroiditis can also lead to an increase in thyroid hormone receptor antibodies. For those who do not have clinical symptoms, they do not need special treatment, and can be followed up and observed on a regular basis. If combined with hypothyroidism, levothyroxine therapy is needed. There are many reasons for the increase in thyrotropin receptor antibodies, so it is recommended that the patient should consult a doctor for examination and choose the appropriate way to deal with the problem.