Cirrhosis with blood in the stool on the toilet may be caused by the patient’s coagulation dysfunction, hypersplenism and gastrointestinal bleeding. Cirrhosis is the end stage of many kinds of chronic liver diseases (e.g. alcoholic liver, fatty liver, etc.), in which there is extensive necrosis of liver cells and massive proliferation of fibrous tissues, leading to deterioration of liver function. According to the development of the disease, cirrhosis can be categorized into compensated and decompensated stages. In the decompensated stage of cirrhosis, liver function is severely impaired, the coagulation factors synthesized by the liver are reduced, hypersplenism and capillary fragility are increased, and the activator of fibrinase cannot be removed efficiently, so that the dissolution of fibrin is increased, which leads to the patient’s coagulation dysfunction, or platelet reduction, which can cause the blood not to be easily coagulated, and blood pulling in stools occurs. In addition, patients with cirrhosis in the uncompensated stage will also have increased portal vein pressure, esophagogastric fundus varices, and in severe cases, blood vessel rupture and bleeding can occur, and when the bleeding is large, the symptom of blood in stool can occur. When patients with cirrhosis have blood in the stool when going to the toilet, it means that they have entered the uncompensated stage, and the loss of blood can be life-threatening, so it is recommended that the patients seek medical treatment in a timely manner and accept treatment actively to avoid delaying the condition.