Isotretinoin Soft Capsules are useful and effective in the treatment of severe refractory nodular acne. The main ingredient of Isotretinoin Soft Capsules is isotretinoin, which is indicated for the treatment of severe refractory nodular acne, these damages can be accompanied by pus or bleeding. Because of the high number of adverse reactions to isotretinoin, this medication should be used when other conventional treatments have failed and/or when the condition is severe. Adverse reactions to Isotretinoin Soft Capsules are more frequent and include allergic reactions, hepatic impairment, nausea and other gastrointestinal damage, anemia, osteomalacia, tinnitus, and corneal clouding. Because it can cause fetal malformation, it can not be used for pregnant or potentially pregnant women, and should be strictly contraceptive during use. It is forbidden for those who are allergic to this product, women who are pregnant or about to become pregnant, breastfeeding women, liver and kidney insufficiency, this drug should be used under the supervision of a physician.