Membranous nephropathy and tethered proliferative nephritis are two different types of nephropathy, both of them have their own developmental stages, and their severity cannot be compared simply and cannot be generalized. Membranous nephropathy and tethered proliferative nephritis have different pathologies, clinical manifestations and treatments. In terms of pathology, membranous nephropathy refers to the thickening of the basement membrane of the glomerulus, whereas, in the case of membranoproliferative nephritis, there is a severe proliferation of mesangial cells, mesangial stroma, and thickening of the basement membrane. In terms of pathologic changes, thylakoid nephritis is more severe and has a wider range of lesions than membranous nephropathy. In terms of clinical manifestations, the clinical manifestation of membranous nephropathy is nephrotic syndrome, while most of the patients with thylakoid proliferative nephritis have manifestations such as chronic nephritis syndrome and nephrotic syndrome. In terms of treatment, most of the membranous nephropathy can be cured clinically by applying hormone and immune agent treatment, and some of them can maintain stable renal function for a long time. While most of the patients with mesangial proliferative nephritis are insensitive to glucocorticoids and immunosuppressive agents development may be faster. However, both may progress to renal failure. Regardless of the presence of membranous nephropathy or mesangial proliferative nephritis, it is recommended to consult a doctor in time, and under the guidance of the physician active treatment.