The so-called “F4” refers to four words beginning with the English letter F, that is, Forty (40 years old), Fat (obesity), Female (female), Fertile (multiple births). First, Forty (40 years old) into middle age, people’s physical activity is reduced, and a large amount of fat accumulation in the body, the human body began to “blossom”, this time the gallbladder function is weakened, the bile duct peristalsis slowed down, the bile stagnation, easy to induce cholecystitis and cholelithiasis. Middle-aged people around 40 years old, due to the pressure of work, lifestyle changes, there are often different degrees of neuromodulation and metabolic disorders, affecting the normal contraction and diastole of the gallbladder, so that bile excretion is not unobstructed. Slowly fat middle-aged people, due to fat metabolism disorder, more likely to stimulate the gallbladder strong contraction. Second, Fat (obesity) people eat, under neural regulation, the gallbladder contraction, bile through the bile duct into the duodenum, to promote the digestion and absorption of fat. And obese people usually like to eat high cholesterol and high fat diet, so the blood and bile cholesterol content is also significantly higher, so that cholesterol is in a supersaturated state. In this case, cholesterol is easy to precipitate, precipitation, the formation of stones. Third, Female According to statistics, the incidence of gallbladder disease, especially gallstones, is 3-4 times higher than that of men. Compared with men, women are reluctant to be active, less physical labor, and often have a sedentary habit. This makes the gallbladder contraction force decline, bile duct opening sphincter dysfunction, gallbladder emptying delay, bile stagnation, conducive to bacterial reproduction, stone formation. In addition, by the role of estrogen in the female body, middle-aged and elderly women are more likely to be fat than men, blood and bile cholesterol content increases. Pre-menopausal middle-aged women, because of endocrine changes, often affect the secretion and regulation of bile, so the chances of getting cholecystitis than men of the same age. Fertile (multiple births) Pregnancy is a trigger for the formation of gallstones and cholecystitis. Normally, after childbirth and breastfeeding, fat metabolism returns to its original level. However, multiple births can disrupt cholesterol metabolism, creating opportunities for cholecystitis and gallstones to form. The most cost-effective solution to prevent cholecystitis is to eat three times a day on time, especially breakfast breakfast, do not let the digestive function disorder. In addition, you should also pay attention to eat less high cholesterol food, and eat more fruits and vegetables containing vitamin A, such as carrots, spinach, apples and so on. In addition, strengthen the movement and exercise, especially the office family sedentary after timely exercise, running and jumping, can enhance the gallbladder diastolic function. Finally, obesity and hyperlipidemia patients, pay attention to lifestyle modification is essential, appropriate weight loss at the same time, the application of lipid-lowering drugs, can also reduce the chance of stone occurrence.