The causes of low globulin mainly include physiological factors, immune function suppression, severe liver function damage, kidney disease or congenital disease. 1. Physiological factors: low globulin can occur in infancy and early childhood, such as before the age of three, which is a normal physiological factor. 2. Immunosuppression: If immunosuppressants or adrenocorticotropic hormones are used for a long period of time, it will easily lead to immunosuppression, which will result in the phenomenon of low globulin in the body. 3. Serious liver function damage: If liver function is seriously damaged, it will easily affect the metabolism of the body and produce the problem of low immune function, thus causing low globulin. 4. Kidney disease: if there are kidney diseases, such as diabetic nephropathy or renal insufficiency, it will easily affect the protein metabolism, which will lead to low globulin. 5. Congenital diseases: If there is congenital hypoglobulinemia, it is easy to cause low globulin in the body. If the situation is more serious, it is necessary to check the cause of the disease before treatment, and pay attention to regular review in the process of recovery.