Esophageal pain can be treated with amoxicillin, omeprazole, and thioglycollate drugs, and those caused by esophageal cancer need to be treated with surgery. Most of the esophageal pain is caused by damage to the mucosa of the esophagus, and it is common to have patients with esophagitis, which can be treated with medication. Some patients with esophageal pain are caused by Candida or Mycobacterium tuberculosis infection in the esophagus, and can be treated with anti-infective drugs, such as amoxicillin, which can achieve a broad-spectrum antibiotic effect and can destroy most of the bacteria, while being able to prevent infection. Omeprazole can inhibit the secretion of gastric acid and reduce the damage caused to the esophageal mucosa when reflux occurs due to excessive secretion of gastric acid. Aluminum thioglycollate has the effect of protecting the esophageal mucosa and can promote the repair of the esophageal mucosa. In some people, esophageal pain is caused by esophageal tumor, which can threaten the health of patients. After diagnosis, surgical resection treatment should be carried out in time, and after surgery, radiotherapy and chemotherapy should also be combined to inhibit the spread and recurrence of tumor.