Antihypertensive drugs generally take effect 1-2 hours after taking the drug, and for short-acting preparations, they can take effect in about half an hour, and if the drug is taken sublingually, it is possible that it can take about 10 minutes to take effect. Some of the long-acting antihypertensive drugs take 2-4 weeks to reach maximum efficacy, and some drugs, such as telmisartan, may take 4-8 weeks to reach maximum efficacy. Therefore, in clinical practice, if a patient takes an antihypertensive drug and does not achieve the blood pressure control standard doctors will not immediately recommend a change of medication, but take a period of time before considering whether to combine drugs, or change the drug use program. The disadvantage of long-acting agents is that it takes longer to achieve maximum efficacy, while short-acting antihypertensive drugs work faster, but relatively speaking, they cannot maintain the patient’s blood pressure level more stably.