Coldness in the calves is usually the result of pathologic factors, such as atherosclerosis of the lower extremities, varicose veins of the lower extremities, and diabetic peripheral neuropathy. These diseases may lead to cold calves. 1. Arteriosclerosis of the lower limbs: due to factors such as dyslipidemia, hypertension, diabetes, etc., the blood vessels of the lower limbs are occluded or narrowed, blood circulation is blocked, and the blood supply to the tissues is insufficient, which leads to the sensation of coldness in the calves. 2. Varicose veins of the lower limbs: Varicose veins of the lower limbs are caused by defective venous valves, increased venous pressure, etc., which leads to obstruction of venous return, resulting in a feeling of coldness in the legs and the symptom and sensation of coldness in the calves. 3. Diabetic peripheral neuropathy: high blood sugar causes metabolic abnormality and microangiopathy, which in turn triggers peripheral nerve damage, resulting in sensory abnormality, which may be manifested as coldness in the lower limbs, including the calves. In addition, rheumatoid arthritis may also lead to cold calves. If the coldness in the calves is difficult to be relieved on its own, it is recommended to go to the hospital in time to find out the cause and treat it under the guidance of the doctor.