Glutamyltransferase 146 and normal liver on ultrasound should be treated according to the cause. Common causes include liver viral infection, heavy alcohol consumption and drug factors. Commonly used treatments include general treatment, drug treatment and so on. 1. Liver viral infection: Hepatitis virology test should be carried out in time, adequate rest, reasonable diet, avoiding alcohol consumption and overwork. Use antiviral drugs such as interferon, lamivudine, entecavir, etc. When accompanied by gastrointestinal bleeding, vasoactive drugs such as terlipressin can be used, meanwhile, drugs to protect the liver such as compound glycyrrhizin tablets can be used. 2. Heavy drinking: stop drinking alcohol and actively use hepatoprotective drugs such as hepatoprotective tablets and glucuronolactone tablets to reduce transaminases and protect liver function. 3. Drug factors: some drugs such as simvastatin can cause serious liver damage during treatment, which can lead to the elevation of glutamyltransferase, and should be immediately discontinued, and can be treated with the above mentioned liver-protecting drugs at the same time. Glutamyltransferase 146, ultrasound liver may be normal, there may be other reasons such as bile duct obstruction, etc., it is recommended to improve the examination in time to clarify the cause of the disease, and standardized treatment under the guidance of the doctor. The above drugs should be used reasonably under the guidance of the doctor, avoid self-medication.