Occasional heavy lifting usually has no effect on follicles, but prolonged heavy lifting may cause physical strain and affect follicles. The main factors affecting follicle development include hormones secreted by the hypothalamic-pituitary-ovarian axis, cytokines that regulate follicle development in the body, and the genes that regulate them. Occasional heavy lifting does not cause hormone disruption, cytokine or gene regulation abnormalities, so it generally has no effect on follicles. However, for women who carry heavy loads for a long period of time and perform heavy physical labor, overwork will cause physical exhaustion, and some may even suffer from malnutrition and decreased immunity. These adverse factors may cause endocrine dysfunction, abnormal regulation of cytokines in the body, and ultimately affect the follicles. Therefore, for women with reproductive needs, it is recommended to avoid prolonged heavy lifting and heavy physical labor, and to maintain balanced nutrition, adequate sleep, and a happy mood in order to avoid adverse effects on the follicles as much as possible.