Hashimoto’s thyroiditis with nodules can be treated with levothyroxine and glucocorticoids. However, taking the drugs can only improve some of the clinical symptoms, but not eliminate the nodules. 1. Levothyroxine: Hashimoto’s thyroiditis can cause thyroid cell apoptosis and thus destruction of thyroid follicles, resulting in impaired thyroid function and hypothyroidism, which can be ameliorated by taking levothyroxine tablets. 2. Glucocorticoids: Prednisone is commonly used, and can be used when the nodules of Hashimoto’s thyroiditis are rapidly enlarged and accompanied by pain or pressure symptoms. It is contraindicated in patients with drug allergy, hypertension, glaucoma, gastric ulcer and psychosis. Adverse reactions such as centripetal obesity, gastric ulcers, infections, bleeding tendencies, necrosis of the femoral head may occur with the use of the drug. Check out Hashimoto’s thyroiditis with nodules, you should go to the hospital in time, improve the examination, according to the doctor’s guidance and recommendations to take medication or surgical treatment.