There are ways to control cancer progression, improve disease prognosis and prolong survival time after lymphatic metastasis of gallbladder cancer, which can be controlled by comprehensive treatments such as surgery, radiotherapy and targeted therapy. Gallbladder cancer is one of the common malignant tumors of biliary system, and its etiology is still unclear, mostly related to gallbladder stones, gallbladder polyps, chronic inflammation of bile ducts, obesity and diabetes. In case of gallbladder cancer combined with regional lymph node metastasis, surgical resection combined with regional lymph node dissection can usually be given, and postoperative adjuvant chemotherapy (gemcitabine combined with cisplatin regimen), radiotherapy and other therapeutic means can be given to improve the patient’s prognosis; For patients with gallbladder cancer combined with distant lymph node metastasis, if the situation permits, surgical resection can be given to the primary foci, local radiotherapy can be given to the metastatic foci, and adjuvant chemotherapy and targeted therapy can be given to improve the patient’s prognosis. For patients who are suspected or diagnosed with gallbladder cancer, it is recommended to go to regular hospitals for comprehensive evaluation of their conditions, follow the doctor’s instructions, and choose appropriate treatment plans to avoid delaying their conditions.