Whether elevated platelets can be vaccinated with the New Crown vaccine is recommended to be divided into situations, including physiological and pathological reasons. 1. If the platelet elevation is caused by physiologic reasons, the vaccine can be administered. 2. If the platelet elevation is caused by pathological reasons, it is recommended that the new crown vaccine should not be given for the time being, such as chronic granulocytic leukemia, anemia, primary thrombocythemia and other diseases. (1) Chronic granulocytic leukemia: referred to as chronic granulomas, is a clonal disease characterized by anemia, increased peripheral blood granulocytes and the presence of various stages of naïve cells and basophilia, often with thrombocytosis and splenomegaly, and originating from pluripotent hematopoietic stem cells. (2) Anemia is a pathological condition in which the number of red blood cells per unit volume of circulating blood, the hemoglobin content and the hematocrit are lower than normal. It can be caused by a variety of reasons, such as decreased erythropoiesis, blood loss and hemolysis, and is manifested by pale skin and mucous membranes and dizziness. (3) Primary thrombocythemia: it is mostly caused by abnormal proliferation of the megakaryocyte system due to abnormal proliferation of bone marrow, which leads to elevated platelets in peripheral blood. If the high platelet is caused by the disease, then these patients are not recommended to receive the new crown vaccine for the time being. It is best to diagnose the cause of the platelet elevation, look at the specific situation, and receive treatment under the guidance of a physician before deciding whether to proceed with vaccination.