Terminal ileal ulcers can be caused by Crohn’s disease or by other diseases, such as chronic inflammation of the ileum and intestinal tuberculosis. Crohn’s disease occurs mainly in the terminal ileum, and its etiology is still unclear. It mainly causes segmental ulcers at the lesion site, and patients may experience clinical symptoms such as abdominal pain, diarrhea, etc. Due to poor intestinal absorption of nutrients, some patients may also experience malnutrition such as wasting. But not all ileal ulcers are Crohn’s disease, some of the ileum part of the chronic inflammation, tuberculosis mycobacterium infection and other diseases, can also lead to abdominal pain, diarrhea and other symptoms, intestinal mucosa long-term stimulation of inflammation, may also appear ulcerated. Patients with ulcers at the end of the ileum, it is important to consult a doctor in a timely manner to identify the cause, take targeted treatment measures, do not miss the condition.