The yellowing of urine after taking Huang Lian Shang Qing Pill is mostly considered to be caused by staining, because Huang Lian Shang Qing Pill contains yellow pigment and Huang Lian ingredients, so it will lead to yellow staining of urine, which is a normal phenomenon and need not be overly worried. If the patient is overly concerned, you can stop the drug to observe whether the urine color returns to normal, and keep the urine for relevant urine tests to understand whether there are abnormal urine composition indicators; or increase the amount of water during taking the drug, which can play a role in diluting the urine to reduce the phenomenon of yellow urine; at the same time, you need to further inquire whether the patient has a history of frequent urination, urinary urgency, painful urination. If there is a combination of urinary tract infection during the medication period, the yellowing of urine can be aggravated and a routine urine test is needed to further confirm the diagnosis.