Pregabalin and gabapentin are both effective in the treatment of postherpetic neuralgia, but the specific efficacy varies from person to person, and it is not possible to clearly determine who is better. Pregabalin is suitable for the treatment of postherpetic neuralgia and fibromyalgia, the mechanism of action is not clear. It should be contraindicated in people who are allergic to the product. Common adverse reactions include dizziness, drowsiness, dry mouth, edema and blurred vision. Gabapentin is indicated for the treatment of postherpetic neuralgia in adults and as an adjunct to the treatment of partial-onset seizures with or without secondary generalized seizures in children and adults over the age of 12 years or in children aged 3 to 12 years. It should be contraindicated in people who are allergic to the product and in people with acute pancreatitis. Common adverse reactions to the drug include dizziness, fatigue, drowsiness, peripheral edema, seizures, headache, and nausea. Both drugs can be used in the treatment of postherpetic neuralgia, the specific efficacy varies from person to person and it is not possible to state clearly who is more effective. Specific medication should be used under the guidance of a specialist.