Headache and lymphatic pain are mainly seen for the following reasons: First, when in the acute stage of acute infection or viral infection the patient has high fever and headache, accompanied by swollen lymph nodes, with swollen lymph nodes in the angle of the jaw behind the ear as obvious, also accompanied by lymph node pain, a routine blood test can be done, considering that there is a relationship with the reactivity caused by inflammation. Second, if it is a chronic and persistent process, the patient does not have obvious fever but has symptoms of malaise, the patient should be asked if there is any generalized lymph node enlargement, at which time the patient needs to be considered as having a hematologic disease, such as the possibility of lymphoma. Bone marrow aspiration examination and cranial magnetic resonance examination are needed to understand whether there is any lesion caused by lymphoma invading into the skull, and the patient may also show headache and lymphatic pain.