In patients with diabetic nephropathy, hypoglycemia often occurs because of medication, diet control, excessive exercise, inappropriate insulin dosage, etc. However, recurrent hypoglycemia significantly increases the risk of stroke and death in patients with diabetic nephropathy. The findings from the study “Impact of hypoglycemia on cardiovascular prognosis in patients with chronic kidney disease (CKD)” conducted by scholars from China and Taiwan showed that CKD was associated with an increased risk of stroke and death in patients with hypoglycemia; repeated hypoglycemia significantly increased the risk of stroke and death in patients with CKD. Repeated hypoglycemia significantly increased the risk of stroke and total death in patients with CKD. The findings further suggest that hypoglycemia plays a critical role in the development of stroke and death in CKD patients. A total of 46,135 patients with CKD were included in the study, and 2,117 patients (4.59%) were hospitalized and had hypoglycemia. The analysis showed that stroke, coronary heart disease, congestive heart failure and death were correlated with the occurrence of hypoglycemia in CKD patients. The experts took a multiple proportional risk regression analysis. Recurrent hypoglycemic episodes were associated with a higher risk of death and other multiple cardiovascular events (HR = 33.0). Patients who developed hypoglycemia had an increased risk of stroke and total death compared to those without hypoglycemia. Patients with diabetic kidney disease, mostly chronic kidney disease (CKD), are highly susceptible to hypoglycemia during the treatment of diabetes. The danger of hypoglycemia is much greater than that of hyperglycemia alone, so our diabetes experts believe that multidisciplinary experts work together to develop treatment and control programs, and that eliminating hypoglycemia is the first goal of the program, followed by controlling hyperglycemia and controlling diabetic nephropathy.