High total protein and high total bilirubin may be caused by physiological factors such as staying up late and mental stress, or by diseases such as cirrhosis and viral hepatitis A. They can be improved by general treatment and medication. 1. Physiological factors: if the total protein and total bilirubin are high due to frequent late nights and mental stress, no special treatment is needed; regular daily routine, sufficient sleep and pleasant mood can be achieved. 2. Cirrhosis: high total protein and total bilirubin may also be caused by cirrhosis, patients should ban smoking and alcohol, pay attention to rest. For patients with compensated hepatitis B cirrhosis, they can take antiviral drugs such as tenofovir and entecavir as prescribed by the doctor. For patients with compensated hepatitis C cirrhosis, they can take daclatasvir, sofosbuvir and other drugs as prescribed by doctors. 3. Viral hepatitis A: Viral hepatitis A can also lead to high total protein and total bilirubin, patients should pay attention to their diet and avoid oily food. The patients should pay attention to their diet and avoid eating greasy food. They can take liver-protecting drugs such as silymarin preparation and glycyrrhizic acid preparation as prescribed by the doctor. For patients with serious condition, they should also take injections of diammonium glycyrrhizinate or oral drugs such as glycyrrhizin sweeteners to promote the regrowth of hepatocytes as prescribed by the doctor. The causes of high total protein and high total bilirubin are many, after excluding physiological factors, it is recommended to go to the hospital for examination and cooperate with the doctor for standardized treatment.