Abnormal immune function is related to physiological factors such as fatigue, excessive smoking and drinking, as well as drugs and autoimmune diseases. 1. Physiological factors: common causes include long-term overwork, work and rest disorders, not enough rest time; followed by excessive smoking and alcohol abuse, which damages the immunity of the body, and to a certain extent, will lead to abnormal immune function and reduce the body’s defense ability. 2. Drugs: Studies have shown that when patients use anti-tuberculosis, anti-epileptic or anti-depressant drugs, some of them may experience immune dysfunction due to the impact of these drugs on the immune response of the body. 3. Autoimmune diseases: clinically seen in systemic lupus erythematosus, rheumatoid arthritis, dry syndrome, systemic vasculitis and other diseases, these diseases are through autoimmune reaction, destruction and damage to their own tissues and cells, resulting in organ dysfunction, which in turn cause immune function abnormalities. It is recommended that people with abnormal immune function go to the rheumatology and immunology department of regular hospitals for further clarification of the cause of the disease.