The principle of chronic pain treatment is not “treating the symptoms but not the root cause” as most patients and some medical professionals usually understand, but “treating both the symptoms and the root cause”. 1. Blocking the nerve conduction pathway of nociception. 2. Block the vicious cycle of “pain → muscle tension or small-vessel smooth muscle spasm → local ischemia → tissue hypoxia, metabolite accumulation → increase of pain-causing substances → neuroplasticity reaction → increase of pain”. 3. Reduce sympathetic excitability, dilate blood vessels, improve blood circulation and tissue metabolism. 4. Anti-inflammatory effect, eliminating local non-bacterial and immune neuroinflammation. 5. Improving the patient’s mood, adjusting the psychological state and raising the pain threshold. 6. Relieve the compression of nerves by various diseased tissues such as cervical/lumbar disc herniation, osteophytes, scarring, inflammatory hyperplasia, etc. Treatment is a combination of oral medication, nerve block, anti-inflammatory and analgesic injection therapy at the precise lesion site, local chemical nerve destruction therapy, and minimally invasive interventional surgical treatment under the guidance of imaging electrophysiology.