Doxycycline ophthalmic ointment, also known as tobramycin dexamethasone ophthalmic ointment, is a compounded ophthalmic ointment formulation consisting of tobramycin and dexamethasone as the main ingredients. Tobramycin is an antibiotic with antibacterial activity against Staphylococcus aureus, Staphylococcus epidermidis, and Streptococcus, as well as pathogens of the Enterobacteriaceae family. Dexamethasone is a glucocorticoid that inhibits inflammatory responses caused by various factors and may also delay wound healing and may inhibit the body’s defenses against infection. If there is a pathogenic infection, it is important to use a combination of antibiotics, which act synergistically with tobramycin. It can be used clinically primarily for inflammatory ophthalmic lesions, and bacterial infections of the ocular surface, or in situations where there is a risk of infection. In conclusion, tobramycin dexamethasone ophthalmic ointment can be used mainly for inflammatory diseases of the eye.