Cold and yellow nose can be treated with drugs in the following cases: First, if the symptoms of cold and yellow nose appear, antihistamine drugs, such as chlorpheniramine maleate, can be used for treatment, and also antipyretic and antiviral drugs, such as Xiao Chai Hu granules and Ban Lan Gen Punch, which are beneficial to the recovery and shorten the course of the disease. Secondly, if the cold, runny nose with headache and fever over 38.5℃, you can use antipyretic and analgesic drugs according to the situation, mainly acetaminophen and ibuprofen; thirdly, the cold, runny nose can be treated with pseudoephedrine hydrochloride to relieve the symptoms of nasal congestion and runny nose, yellow nose indicates bacterial infection, and antibiotic treatment needs to be given. Usually pay attention to keep warm, eat more fruits and vegetables and pay attention to rest, when the symptoms of cold and yellow nose appear, go to the hospital in time for treatment under the guidance of the doctor.