Central cyanosis is a type of cyanosis, which is a manifestation of increased reduced hemoglobin in the blood, or the presence of abnormal hemoglobin derivatives, resulting in cyanotic changes in the skin mucosa, also called cyanosis. It causes central cyanosis mainly in severe cardiopulmonary diseases, mostly due to abnormal cardiopulmonary function, resulting in impaired gas exchange and decreased oxygen saturation. Common diseases include laryngeal, tracheal, and bronchial obstruction, as well as chronic obstructive pulmonary disease, diffuse interstitial pulmonary fibrosis, pulmonary stasis, pulmonary edema, pulmonary embolism, and acute respiratory distress syndrome. Cardiac diseases, such as congenital heart disease, acute and chronic heart failure from various causes, can also cause cyanosis. Central cyanosis is characterized by cyanosis as generalized cyanosis with warm cyanotic skin.