Exfoliative dermatolysis bullosa is generally referred to as exfoliative keratolysis, and its treatment includes general therapy and medication. Exfoliative keratolysis is a kind of superficial exfoliative dermatosis that occurs in the palm and plantar area in the form of dots and flakes. 1. General treatment: usually pay attention to the cleanliness of the skin, reduce the contact with stimulating substances, at the same time, can be applied to the appropriate hand cream and so on. 2. Medication: Salicylic acid ointment and Vitamin E ointment are commonly used for topical treatment. Some patients can apply vitamin A and other drugs for systemic treatment. The use of specific drugs should be carried out under the guidance of a doctor, and if there is any discomfort, it is recommended to consult a doctor in time for diagnosis and treatment.