There is no so-called special medicine for the treatment of esophageal hiatal hernia, and commonly used drugs include ranitidine, mosapride, aluminum hydroxide gel and omeprazole. Esophageal hiatal hernia refers to the abdominal tissue or organ through the diaphragmatic esophageal hiatus into the thoracic cavity resulting in disease, including esophageal hernia, sliding hiatal hernia and mixed hiatal hernia three types, with the sliding hiatal hernia is more common, accounting for about 75% to 90%. Esophageal hiatal hernia is mainly treated by internal medicine, and only a few patients need surgery. Commonly used drugs for the treatment of this disease include proton pump inhibitors such as omeprazole and rabeprazole, prokinetic agents such as mosapride and domperidone, esophageal mucosal protectors such as aluminum hydroxide gel, and proton pump inhibitors such as rabeprazole and omeprazole. In addition, in daily life, patients should pay attention to small meals, avoid spicy stimulating food, avoid fullness, avoid lying down immediately after eating. The above drugs are prohibited for those who are allergic to them, and they should all be taken in accordance with medical advice. If the patient is diagnosed with esophageal hiatal hernia, it is recommended to go to the regular hospital in time, under the guidance of the doctor to carry out targeted treatment, in order to reduce the adverse effects of the disease.