Pain in the ankle may be caused by gout attack, or rheumatoid arthritis, degenerative joints and other factors. 1. Gout attack: gout is urate crystals in the joints and the surrounding soft tissue aggregation, adhesion and trigger a series of inflammatory response, patients can therefore appear joint pain, joint swelling and other symptoms, gout occurs in the ankle can lead to pain in this area. 2. Rheumatoid arthritis: rheumatoid arthritis mainly involves the ankle, knee, wrist and other peripheral joints and leads to symmetrical, erosive joint inflammation, when it involves the ankle joints, it may cause pain in the ankle. 3. Degenerative joint changes: Degenerative joint changes, i.e. osteophytes, can be caused by overloading or imbalance in the distribution of mechanical stress, resulting in wear and tear of articular cartilage, which can lead to joint pain, redness and swelling of the joints. There may be other causes of ankle pain, so we suggest that patients go to the rheumatology and orthopedics departments of regular hospitals to further clarify the causes of the disease and follow the doctor’s instructions for standardized treatment.