TP can medically refer to total protein, which is a test that is often seen in liver function and includes albumin and globulin. elevated TP can be seen in elevated globulin, which may be a myeloproliferative disease, or an infection, or autoimmune disease. A decrease in total protein can be seen in a decrease in albumin, which may be due to a significant decrease in albumin production in cirrhosis, or an increase in albumin in nephrotic syndrome, often seen as edema. tp can also medically refer to pale dense spirochetes, which are the etiologic agent of syphilis. Syphilis is a sexually transmitted disease that can be transmitted through sexual intercourse, mother to child, and blood. When a person is infected with stage I syphilis, a hard chancre may appear, stage II syphilis a syphilis rash, and stage III syphilis even has cardiovascular or neurosyphilis related damage. Syphilis can be cured by treatment with penicillin and other drugs.