The etiology of eyelid xanthoma is mainly related to the body’s lipid metabolism abnormality, and some skin lesions may also lead to this disease, which is mainly manifested as yellow papules or plaques on the eyelids and inner canthus. The disease is mainly related to lipid metabolism disorders in the body, such as hypercholesterolemia, hyperlipoproteinemia, etc., and the occurrence of secondary hyperlipoproteinemia is related to diabetes mellitus, thyroid dysfunction, diet, etc., so these factors are the most common causes of dyslipidemia, resulting in the appearance of eyelid xanthomas. Some skin lesions may also lead to the development of this disease without affecting the body’s lipid level, such as erythroderma, inflammatory skin diseases, allergic contact dermatitis, etc., which may also lead to the manifestation of eyelid xanthomas. It is recommended that people with yellow papules, orange plaques or nodules on the eyelids should seek prompt medical attention to confirm the diagnosis of the disease, such as clarifying the body’s blood lipid levels, and to undergo regular treatment as needed.