During many clinic sittings, I am often asked the same question by patients, “Physician, can my mastocytosis be cured?” Why do many female patients ask this question? I think it may be because they think mastopexy is a disease and they are worried about it and hope it can be cured. The development of breast is closely related to estrogen and progesterone in the body. Among them, estrogen mainly stimulates the development, growth and hyperplasia of breast lobules; progesterone mainly stimulates the proliferation and growth of breast ducts. When a woman’s secondary sexual characteristics develop, that is, when she has her first menstrual period, her breasts will change with the changes in the hormone levels of the ovaries. In the pre-menstrual period, the estrogen level rises significantly, the entire breast lobules increase significantly, and the breasts increase in size, so there will be swelling and pain in both breasts before menstruation; after the menstrual period, the estrogen level decreases, and the breast glands return to their normal size, so the swelling and pain in both breasts will be relieved or eliminated. Therefore, as long as there is menstruation, mammary gland hyperplasia can not be cut off, until after menopause, menstruation is completely gone, no cyclical changes in estrogen, and the mammary glands are not proliferating again, slowly shrinking. To conclude, if there is no obvious discomfort, mammary gland hyperplasia does not require treatment and does not require much attention. If it appears to be obvious that there is significant swelling and pain in both breasts, which is still obvious after menstruation and affects daily life, etc., then treatment is needed.