Lung squamous cancer combined with liver metastasis needs to receive comprehensive treatment, such as radiotherapy, chemotherapy and targeted therapy individually or in combination. Liver metastasis of squamous lung cancer suggests that the patient is already in advanced stage, usually the chance of surgical resection has been lost, and multidisciplinary and comprehensive treatment is usually recommended. 1. Chemotherapy: Liver metastasis of squamous lung cancer usually belongs to advanced stage, which has missed the best time for surgical resection, clinically, chemotherapy is often considered, and single-drug chemotherapy such as docetaxel and gemcitabine can be used. 2. Radiotherapy: Radiotherapy is used for systemic and local treatment, which can help to reduce the size of tumor and relieve the discomfort of patients. 3. Targeted therapy and immunotherapy, such as the existence of genetic mutations in patients, can also be targeted therapy, precise action on the tumor, prolonging the survival period, commonly used drugs are gefitinib, ectinib, erlotinib, pabolizumab, tirilizumab and so on. In addition, for liver metastases, interventional therapy (transhepatic artery chemoembolization, radiofrequency ablation, etc.) can be given to control the metastases. It is recommended that patients with squamous lung cancer combined with liver metastasis should go to regular hospitals to evaluate their conditions and follow the doctor’s instructions to cooperate with the treatment, so as to avoid delaying their conditions.