The difference between magnesium valproate extended-release tablets and sodium valproate is the drug composition as well as contraindications. Both are used to treat generalized and partial epilepsy, as well as mania. Magnesium valproate extended-release tablets are medium- to long-acting drugs, but sodium valproate is also available in extended-release formulations, and the difference between the two is not significant. 1. drug composition: magnesium valproate extended-release tablets main drug ingredients for magnesium valproate, chemical name 2-propyl magnesium valproate. Sodium valproate extended-release tablets are mainly composed of sodium valproate, chemically known as sodium 2-propylvalerate. 2. Contraindications: magnesium valproate extended-release tablets are contraindicated for those who are allergic to valproic acid drugs, leukopenia, porphyria and severe liver disease, and are used with caution in the presence of a history of liver disease, renal impairment, hematologic disorders, and organic encephalopathy. And sodium valproate is contraindicated in patients who are allergic to sodium valproate, have a history or family history of severe hepatitis, hepatic porphyria, acute and chronic hepatitis, and patients suffering from urea cycle disorders. The difference between magnesium valproate extended-release tablets and sodium valproate is not obvious, and it is recommended that patients strictly follow the doctor’s instructions to avoid unauthorized change of medication on the condition.