The drug should be discontinued immediately after acetaminophen poisoning, oral poisoning immediately induced vomiting, thorough gastric lavage, diarrhea, to minimize the absorption of the drug into the body, but also a lot of rehydration to speed up the excretion of the absorbed drug, heavy on blood purification, direct removal of the drug in the blood, to early, correct, regular use of acetaminophen special antidote, such as N-acetylcysteine, and strive to use within 10 hours after the overdose. The effect will be very poor if used more than 24 hours later. Acetaminophen poisoning will mainly damage the liver and cause serious liver damage, so it is necessary to protect the liver with hepatoprotective drugs, such as reduced glutathione, to slow down liver damage. If liver and kidney failure occurs, artificial liver and kidney should be used to save the patient.