The causes of numbness of toes include diabetic peripheral neuropathy, lumbar spine disease, Green-Barre syndrome, etc. 1. Diabetic peripheral neuropathy: If diabetic patients’ blood sugar control is not good can cause impaired peripheral nerve function, there can be symptoms of numbness in toes. 2. Lumbar spine disease: In lumbar spine disease, herniated disc or lumbar spinal stenosis compresses the nerves in the lumbar region, and symptoms of numbness in the toes can appear, which can be diagnosed by combining with lumbar spine CT or MRI and other examinations. 3. Guillain-Barre Syndrome: This disease will appear the symptoms of muscle weakness of both lower limbs to the upper limbs, and there may be sensory disorders, and the patients may have symptoms such as numbness of the toes. It can be diagnosed with cerebrospinal fluid examination. When this disease develops, it is recommended that patients should go to the hospital outpatient clinic in time, and choose a reasonable treatment plan under the guidance of the doctor.