Perianal abscess surgery is very important, but due to some patients’ condition is relatively heavy, the incision is deeper, the postoperative drug change is very painful, to reduce the pain of drug change, we must do the following: 1, before the drug change around the anus to carry out sufficient warm water cleaning, sitz bath, which can reduce the process of changing the drug in the repeated scrubbing action, reduce pain; 2, in the change of the drug one hour before you can also take an oral Pain medication can also be taken orally one hour before the change of medicine to reduce the pain of the change of medicine; 3, five minutes before the change of medicine can also be applied to the pain gel, the incision to be coated to reduce pain; 4, more important is to change the medicine of the doctor’s movements to be gentle, to be familiar with the surgical access to the incision, so as to avoid misuse leading to the intensification of the patient’s pain. In any case, the change of medicine is very important, even if the pain is severe, can not avoid the change of medicine, otherwise it may be due to the change of medicine is not timely, not thorough, and the incision infection, or even the recurrence of abscesses leading to surgical failure.