Strongly positive anti-SSA antibody and positive ANA often suggest dry syndrome, systemic lupus erythematosus and other diseases. 1. Dry syndrome: After patients suffer from dry syndrome, their anti-SSA antibody is positive, with high specificity, and ANA positivity may also occur; clinically, it is recommended to combine with patients’ clinical manifestations, such as dry mouth, dry eyes and other symptoms, to assist in diagnosis. 2. Systemic lupus erythematosus (SLE): patients with SLE may be positive for ANA antibody, but the specificity is low; if the patient is complicated by vasculitis, skin lesions, leukopenia, etc., strong positivity of anti-SSA antibody may occur. Clinically, it is recommended to combine the patient’s clinical manifestations, such as erythema of the cheeks, discoid erythema and other symptoms, to assist in the diagnosis. If the patient has strong positive anti-SSA antibody and positive ANA, it is recommended to go to the rheumatology and immunology department of the regular hospital in time to improve the examination, make a clear diagnosis and standardize the treatment under the guidance of specialists.