Causes of cortisol increase include physiological and pathological diseases, physiological usually do not need special treatment; pathological diseases include pituitary tumor, adrenocortical disease, ectopic ACTH syndrome, etc., which can be treated with medication and surgery. It is recommended to follow the doctor’s treatment. 1. Physiological causes: such as pregnancy, can cause cortisol increase, do not need special treatment, regular monitoring. 2. Pathological causes: for example, pituitary ACTH tumors, often treated with surgery, and those who cannot be operated can be treated with medication, such as the use of bromocriptine, etc.; adrenocortical tumors, often treated with surgery; ectopic ACTH syndrome, which is caused by tumors such as thymoma and small-cell lung cancer, and the removal of the primary tumor can be considered. High cortisol should go to the hospital to find out the cause and treat according to the cause.