There are many medications for epilepsy, and there are now basically first-, second-, and third-generation antiepileptic drugs. First, antiepileptic drugs need to be selected based on the type of seizure, age and whether the patient is pregnant. Secondly, it is important to choose a drug for epilepsy with few side effects to ensure that the seizures can be controlled. The common drugs with low side effects for the treatment of epilepsy are new antiepileptic drugs, the third generation of oral antiepileptic drugs, such as pirampanel, which is a newer antiepileptic drug on the market, can make the blood concentration of epileptic patients stable, and the treatment effect is better, and its side effects are smaller compared to the second generation of antiepileptic drugs. In addition, there are second-generation antiepileptic drugs commonly used in clinical practice, such as gabapentin, lamotrigine, topiramate, levetiracetam, and pregabalin. These drugs have fewer side effects and fewer drug-drug interactions compared to first-generation antiepileptic drugs. The first generation of antiepileptic drugs in the traditional sense are the older antiepileptic drugs, such as phenobarbital, phenytoin sodium, carbamazepine, valproic acid, clonazepam, etc. These drugs have relatively large side effects compared to second and third generation antiepileptic drugs, with damage to liver function, suppression of bone marrow, and large effects on intelligence and cognition. In addition, it is worth noting that young women try to avoid the use of sodium valproate for epilepsy because of its high teratogenicity. For women who are breastfeeding, pregnant, or of childbearing age, antiepileptic drug therapy that is least harmful and does not affect the fetus should be selected under the guidance of a physician.