Knee pain in the morning can be caused by the following reasons: First, rheumatism and rheumatoid rheumatism, when rheumatism and rheumatoid rheumatism involved in the knee joint, can appear in the morning knee joint pain, can be accompanied by swelling and deformity, knee joint movement is limited, then early blood tests and knee X-ray, CT, to early diagnosis and treatment. Second, osteoarthritis of the knee joint, when there is severe osteoarthritis of the knee joint, there can also be morning knee pain and morning stiffness, then early examination of the knee joint X-rays for early diagnosis and treatment. Third, ankylosing spondylitis, ankylosing spondylitis can involve the knee joint and other joints in severe cases, and knee pain in the morning, accompanied by stiffness, can be accompanied by lumbosacral pain, it is necessary to take early x-ray of the knee joint and sacroiliac joint, blood tests, to early diagnosis and treatment.